What is the rationale behind the necessity for this particular scenario? On occasion, I am required to generate dummy variables when conducting PROC NLMIXED operations. This post offers an effective solution to this issue. For reference, the original post is reproduced below.

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Abstract

Implement the delta method to report the means and confidence intervals of difference scores from log-transformed longitudinal data, so that results can be reported on the original scale of the outcome.

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Introduction

These measures are the Fraction of Missing information (FMI), the relative increase in variance due to nonresponse (RIV), and the Relative Efficiency (RE). They are derived from values of the between, and within imputation variance and the total variance. There exist two versions of the FMI, which are referred to as lambda and FMI.

We usually report these measures of Missing data information in TLGs of sensitivity analyses.

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Background

Exact statistics can be useful in situations where the asymptotic assumptions are not met, and so the asymptotic p-values are not close approximations for the true p-values.

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Background

Study ID: D4191C00004 [ClinicalTrials.gov Identifier: NCT02352948; 一项评估 MEDI4736 (Durvalumab) 作为单一疗法或与 Tremelimumab 联合治疗的影响的全球研究,该研究通过 PD-L1 表达与护理标准对比确定,用于治疗局部晚期或转移性非小细胞肺癌 (ARCTIC) 患者]

Sub-study B has 1 treatment comparison of interest that is considered primary as follows:

  • MEDI4736 20 mg/kg Q4W plus tremelimumab 1 mg/kg Q4W for 12 weeks then MEDI4736 10 mg/kg Q2W for 34 weeks compared with Standard of Care
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Yining Ye, et al. (2013) proposed a group sequential Holm procedure when there are multiple primary endpoints. This method addresses multiplicities arising from multiple primary endpoints and from multiple analyses in a group sequential design.

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