In applications of clinical trials, tested hypotheses are often grouped as multiple hierarchically ordered families. To test such structured hypotheses, various gatekeeping strategies have been developed in the literature, such as series gatekeeping, parallel gatekeeping, tree-structured gatekeeping strategies, etc..
To add details for Section 3.2 in the paper A recycling framework for the construction of Bonferroni-based multiple tests.
Here is an excellent answer I have read when I was in university for the interpretation of interactions in linear model.
A key concept that has led to the development of novel methods for handling multiplicity problems of clinical trials is the concept of \(\alpha\)-propagation (Dmitrienko, Ajit C Tamhane, & Brian L Wiens, General multistage gatekeeping procedures, 2008).
Hypothetical strategy: Several possibilities exist. Some examples include what would have happened if the ICE had not occurred and what would have happened under some alternative regimen, such as if rescue had not been taken. Here, the ICEs are a confounding factor.
The following are standard conventions for time-to-event (TTE) analyses
Given the evolving research and regulatory landscape with multiple versions of irRECIST implemented by different Sponsors and the position from Health Authorities regarding the role of irRECIST (purely exploratory), implementation of irRECIST in new protocols is not recommended.
A simple description of cox regression model.
A simple description of censored data and fundamental survival analysis.
The 1st post to review the Mixed Effect Model.